HCID 20134167, compound → HCID 57572314, compound

HRID 1293165Notes

Reaction equation

HRID 1293165 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:16]([NH:18][CH2:19][C:20]2[CH:29]=[CH:28][C:23]([C:24]([O:26][CH3:27])=[O:25])=[CH:22][CH:21]=2)=[O:17])[C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=[N:6][CH:7]=1.N[CH:31](C1C=CC(C(OC)=O)=CC=1)[CH2:32]C>>[F:1][C:2]1[CH:3]=[C:4]([C:16]([NH:18][CH:19]([C:20]2[CH:21]=[CH:22][C:23]([C:24]([O:26][CH3:27])=[O:25])=[CH:28][CH:29]=2)[CH2:31][CH3:32])=[O:17])[C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 20134167HCID 20134167, compoundHCID 57572271HCID 57572271, compound

Product 1

HCID 57572314HCID 57572314, compound

Procedure

The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-fluoro-2-(4-fluorophenoxy)nicotinic acid (step 3 of Example 1) and methyl 4-(1-aminopropyl)benzoate: 1H-NMR (CDCl3) δ 8.33–8.26 (2H, m), 8.05–7.99 (3H, m), 7.39 (2H, d, J=8.4 Hz), 7.20–7.15 (4H, m), 5.15 (1H, q, J=7.3 Hz), 3.90 (3H, s), 1.92 (2H, dq, J=7.3, 7.3 Hz), 0.95 (3H, t, J=7.3 Hz); MS (ESI) m/z 427 (M+H)+, 425 (M−H)−.

Sources & evidence

ORD record
ord-b916e5bc7d0f4d7dba3f6f4fe8ea5edd
Source dataset
uspto-grants-2007_07
Patent number
US07238714B2

Reaction notes

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