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HRID1293181

反应详情

EQUATION

反应方程式

HRID 1293181 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)c1cc(Cl)cnc1Oc1ccc(F)cc1
HCID17832845

未命名化合物

结构：C[C@H](N)c1ccc(C(=O)OC(C)(C)C)cc1
HCID51358470

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H](NC(=O)c1cc(Cl)cnc1Oc1ccc(F)cc1)c1ccc(C(=O)OC(C)(C)C)cc1
HCID69050742

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-chloro-2-(4-fluorophenoxy)nicotinic acid and tert-butyl 4-[(1S)-1-aminoethyl]benzoate (step 3): 1H-NMR (CDCl3) δ 8.54 (1H, d, J=2.7 Hz), 8.14 (1H, br.s), 8.13 (1H, d, J=2.7 Hz), 7.95 (2H, d, J=8.3 Hz), 7.39 (2H, d, J=8.3 Hz), 7.17–7.11 (4H, m), 5.36 (1H, dq, J=7.2, 7.0 Hz), 1.59 (3H, d, J=7.0 Hz), 1.58 (9H, s); MS (ESI) m/z 415 (M+H)+.