反应详情

The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-chloro-2-[(5-chloropyridin-3-yl)oxy]benzoic acid (step 1) and methyl 4-[(1S)-1-aminoethyl]benzoate hydrochloride (step 3 of Example 5): 1H-NMR (CDCl3) δ 8.41 (1H, d, J=2.0 Hz), 8.28 (1H, d, J=2.5 Hz), 8.13 (1H, d, J=2.8 Hz), 7.96 (2H, d, J=8.4 Hz), 7.45 (1H, dd, J=8.7, 2.8 Hz), 7.37–7.28 (1H, m), 7.31 (2H, d, J=8.4 Hz), 7.20 (1H, dd, J=2.5, 2.0 Hz), 6.90 (1H, d, J=8.7 Hz), 5.37–5.22 (1H, m), 3.91 (3H, s), 1.51 (3H, d, J=6.9 Hz).