HRID1293322

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID459499

未命名化合物

结构：C[C@H](NC(=O)c1cc(Cl)cnc1Cl)c1ccc(C(=O)OC(C)(C)C)cc1

HCID57572256

未命名化合物

PRODUCTS

生成物

结构：C[C@H](NC(=O)c1cc(Cl)cnc1Oc1ccc(-c2ccccn2)cc1)c1ccc(C(=O)OC(C)(C)C)cc1

HCID69417723

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to the procedure described in step 2 of Example 45 from tert-butyl 4-((1S)-1-{[(2,5-dichloropyridin-3-yl)carbonyl]amino}ethyl)benzoate (step 1 of Example 45) and 4-pyridin-2-ylphenol (Tetrahedron, 1998, 54, 1289): 1H-NMR (CDCl3) δ 8.71 (1H, m), 8.56 (1H, d, J=2.8 Hz), 8.19–7.71 (8H, m), 7.41 (2H, d, J=1.8 Hz), 7.29–7.25 (3H, m), 5.36 (1H, m), 1.58 (3H, d, J=7.0 Hz), 1.57 (9H, s).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-21e9cfe883ea42aa83a9c534061259f8
来源数据集: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07238714B2
来源说明: uspto-grants-2007_07

反应 SMILES

Cl[C:2]1[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:25]=[CH:24][C:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])=[CH:6][C:5]([Cl:26])=[CH:4][N:3]=1.[N:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[C:33]1[CH:38]=[CH:37][C:36]([OH:39])=[CH:35][CH:34]=1>>[Cl:26][C:5]1[CH:6]=[C:7]([C:8]([NH:10][C@H:11]([C:13]2[CH:25]=[CH:24][C:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:15][CH:14]=2)[CH3:12])=[O:9])[C:2]([O:39][C:36]2[CH:35]=[CH:34][C:33]([C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][N:27]=3)=[CH:38][CH:37]=2)=[N:3][CH:4]=1