Lithium Hydroxide → HCID 22504796, compound

HRID 1296045Notes

Reaction equation

HRID 1296045 reaction equation
C[O:2][C:3](=[O:34])[CH2:4][C:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][CH2:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][CH2:23][C:24]4[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=4)=[CH:18][CH:17]=3)=[CH:13][C:8]=2[O:7][CH:6]=1.[OH-].[Li+]>>[F:33][C:30]([F:31])([F:32])[C:27]1[CH:28]=[CH:29][C:24]([CH2:23][O:22][C:19]2[CH:20]=[CH:21][C:16]([CH2:15][O:14][C:12]3[CH:11]=[CH:10][C:9]4[C:5]([CH2:4][C:3]([OH:34])=[O:2])=[CH:6][O:7][C:8]=4[CH:13]=3)=[CH:17][CH:18]=2)=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 20770852{6-[4-(4-Trifluoromethyl-benzyloxy)-benzyloxy]-benzofuran-3-yl}-acetic acid methyl ester

Product 1

HCID 22504796HCID 22504796, compound

Procedure

The title compound was prepared in the manner analogous to example 1 using {6-[4-(4-trifluoromethyl-benzyloxy)-benzyloxy]-benzofuran-3-yl}-acetic acid methyl ester and lithium hydroxide. mp 161–163° C.; IR (thin film) cm−1: 1715, 1514, 1331, 1226, 1119, 1069; 400 MHz 1H NMR (DMSO-d6) 12.38 (br s, 1H), 7.68–7.72 (m, 3H), 7.61 (d, 2H, J=8.1 Hz), 7.29–7.41 (m, 3H), 7.18 (d, 1H, J=2.2 Hz), 6.96–7.00 (m, 2H), 6.87–6.89 (m, 1H), 5.19 (s, 2H), 5.01 (s, 2H), 3.58 (s, 2H); MS m/z 455 (M−1). Anal. Calc'd for: C25H19F3O5: C, 65.79; H, 4.20; found: C, 65.54; H, 4.02.

Sources & evidence

ORD record
ord-99f6a7ab58be47b99845c7cba403e6a2
Source dataset
uspto-grants-2007_07
Patent number
US07244763B2

Reaction notes

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