2-{[(Benzyloxy)carbonyl]amino}-3-(3-{[(t-butoxycarbonyl)amino]methyl}-4-methoxyphenyl)-2-propenoic acid methyl ester → Methyl 2-amino-3-(3-[(tert-butoxycarbonyl)amino]methyl-4-methoxyphenyl)propanoate

HRID 1296219노트

반응식

HRID 1296219 반응식
[CH3:1][O:2][C:3](=[O:34])[C:4]([NH:23]C(OCC1C=CC=CC=1)=O)=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([CH2:14][NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH:7]=1>CO.O1CCCC1.[H][H].[C].[Pd]>[CH3:1][O:2][C:3](=[O:34])[CH:4]([NH2:23])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([CH2:14][NH:15][C:16]([O:18][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:17])[CH:7]=1

참가 물질

6

반응물 1

HCID 694858062-{[(Benzyloxy)carbonyl]amino}-3-(3-{[(t-butoxycarbonyl)amino]methyl}-4-methoxyphenyl)-2-propenoic acid methyl ester

생성물 1

HCID 22494331Methyl 2-amino-3-(3-[(tert-butoxycarbonyl)amino]methyl-4-methoxyphenyl)propanoate

시약·촉매·용매 4

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매HCID 8028Tetrahydrofuran용매HCID 178418361HCID 178418361, 화합물용매

실험 절차

4.09 g of 2-{([(benzyloxy)carbonyl]amino}-3-(3-{[(t-butoxycarbonyl)amino]methyl}-4-methoxyphenyl)-2-propenoic acid methyl ester was dissolved in 50 ml of methanol and 20 ml of tetrahydrofuran. 0.41 g of 10% palladium carbon was added, followed by stirring for 64 hours at room temperature in hydrogen atmosphere. The catalyst was removed by filtration and washed with ethyl acetate. The filtrate was evaporated, to give 2.92 g of (2-amino)-3-(3-{[(t-butoxycarbonyl)amino]methyl}-4-methoxyphenyl)propionic acid methyl ester as a colorless oil.

후처리

  1. customThe catalyst was removed by filtration
  2. washwashed with ethyl acetate
  3. customThe filtrate was evaporated

출처 및 근거

ORD 기록
ord-cb97139285394dcba5763f7a514b8bbc
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07244861B2

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