2-Bromothiazole → 5-(2,6-dimethoxypyridin-3-yl)-N-[(3R,4S)-4-ethoxy-1-(1,3-thiazol-2-yl)pyrrolidin-3-yl]-3,6-diethylpyrazin-2-amine

HRID 1297320Notes

Reaction equation

HRID 1297320 reaction equation
C(O[C@H]1CN(C2N=CC=CN=2)C[C@H]1NC1C(CC)=NC(C2C(C)=NC(OC)=CC=2)=C(CC)N=1)C.Br[C:36]1[S:37][CH:38]=[CH:39][N:40]=1.[CH3:41][O:42][C:43]1[C:48]([C:49]2[N:50]=[C:51]([CH2:66][CH3:67])[C:52]([NH:57][C@H:58]3[C@@H:62]([O:63][CH2:64][CH3:65])[CH2:61][NH:60][CH2:59]3)=[N:53][C:54]=2[CH2:55][CH3:56])=[CH:47][CH:46]=[C:45]([O:68][CH3:69])[N:44]=1>>[CH3:41][O:42][C:43]1[C:48]([C:49]2[N:50]=[C:51]([CH2:66][CH3:67])[C:52]([NH:57][C@H:58]3[C@@H:62]([O:63][CH2:64][CH3:65])[CH2:61][N:60]([C:36]4[S:37][CH:38]=[CH:39][N:40]=4)[CH2:59]3)=[N:53][C:54]=2[CH2:55][CH3:56])=[CH:47][CH:46]=[C:45]([O:68][CH3:69])[N:44]=1

Participants

4

Reactant 3

HCID 764302-BromothiazoleHCID 11374683N-[(3R,4S)-4-ethoxy-1-pyrimidin-2-ylpyrrolidin-3-yl]-3,6-diethyl-5-(6-methoxy-2-methylpyridin-3-yl)pyrazin-2-amineHCID 589145715-(2,6-dimethoxypyridin-3-yl)-N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethylpyrazin-2-amine

Product 1

HCID 114885955-(2,6-dimethoxypyridin-3-yl)-N-[(3R,4S)-4-ethoxy-1-(1,3-thiazol-2-yl)pyrrolidin-3-yl]-3,6-diethylpyrazin-2-amine

Procedure

Following the procedure for the preparation of N-[(3R,4S)-4-ethoxy-1-pyrimidin-2-ylpyrrolidin-3-yl]-3,6-diethyl-5-(6-methoxy-2-methylpyridin-3-yl)pyrazin-2-amine but substituting 2-bromothiazole and starting with 5-(2,6-dimethoxypyridin-3-yl)-N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethylpyrazin-2-amine provided the title compound as an amorphous solid. 1H NMR (400 MHz, CDCl3) δ) 7.54, 7.23, 6.52, 6.43, 5.21, 4.92, 4.25, 4.00, 3.97, 3.93, 3.80–3.73, 3.54, 3.44, 2.72, 2.52, 1.33–1.26, 1.18; IR (diffuse reflectance) 2963, 2327 (w), 2187 (w), 2056 (w), 1997 (w), 1604, 1580, 1567, 1538 (s), 1474 (s), 1397, 1377, 1311, 1235, 1031 cm−1 HRMS (ESI) calcd for C24H32N6O3S+H1 485.2335. found 485.2333.

Sources & evidence

ORD record
ord-6480902fe8c345138968f85441457e64
Source dataset
uspto-grants-2007_07
Patent number
US07250418B2

Reaction notes

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