HRID1297617

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

$结构：COC(=O)c1cnc2ccc(/C=C3\SC(N[C@@H]4C[C@H]4c4ccccc4)=NC3=O)cc2c1OC$

HCID178498733

未命名化合物

PRODUCTS

生成物

$结构：COc1c(C(=O)O)cnc2ccc(/C=C3\SC(N[C@@H]4C[C@H]4c4ccccc4)=NC3=O)cc12$

HCID178493595

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To the suspension of 4-methoxy-6-[4-oxo-2-((1R,2S)-2-phenyl-cyclopropylamino)-4H-thiazol-(5Z)-ylidenemethyl]-quinoline-3-carboxylic acid methyl ester (example 1) (50 mg, 0.11 mmol) in methanol (2 mL) was added 1 N aqueous sodium hydroxide solution (0.5 mL, 0.5 mmol). After stirring for 12 hours, the crude product was purified by HPLC (reverse C18, 10%-90% acetonitrile in water in 10 min) to afford 4-methoxy-6-[4-oxo-2-((1R,2S)-2-phenyl-cyclopropylamino)-4H-thiazol-(5Z)-ylidenemethyl]-quinoline-3-carboxylic acid. LC-MS m/e 446 (MH+).

WORKUP

后处理

customthe crude product was purified by HPLC (reverse C18, 10%-90% acetonitrile in water in 10 min)