反应详情

To (3,4-Dichloro-phenyl)-(4-phenyl-thiazol-2-yl)-amine (0.34 g, 1.04 mmol) in DMF (5 mL) was added K2CO3 (0.23 g, 1.71 mmol). After 0.1 hour, [(2-Bromo-4-bromomethyl-phenyl)-difluoro-methyl]-phosphonic acid diethyl ester (0.15 g, 0.34 mmol) was added and the resulting mixture was stirred at room temperature overnight. The reaction was partitioned between ethyl acetate and H2O, after which the organic layer was dried over NaSO4 and concentrated in vacuo. The resulting material was purified via column chromatography (1/1 hexanes/ethyl acetate) to yield 0.176 g (76%) of a clear, colorless oil; 1H NMR (300 MHz, CDCl3) δ 7.84-7.22 (m, 11 H), 6.81 (s, 1 H), 5.23 (s, 2 H), 4.23 (m, 4 H), 1.31 (t, J=7.5 Hz, 6 H).

1. customThe reaction was partitioned between ethyl acetate and H2O
2. dry with materialafter which the organic layer was dried over NaSO4
3. concentrationconcentrated in vacuo
4. customThe resulting material was purified via column chromatography (1/1 hexanes/ethyl acetate)
5. customto yield 0.176 g (76%) of a clear, colorless oil