HRID131099

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22711593

10H-Phenothiazine-2-carboxylic acid

C13H9NO2S

2 次

结构：COC1OCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(C)C

HCID69118046

未命名化合物

2 次

PRODUCTS

生成物

结构：COC1OCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)c1ccc2c(c1)Nc1ccccc1S2

HCID11342902

未命名化合物

收率 21%

PROCEDURE

实验过程

The experimental protocol of this peptide condensation is the same as that described for the synthesis of intermediate 1.1, this time using 10H-phenothiazine-2-carboxylic acid (intermediate 1.10) and L-leucyl-L-leucyl-N1-[(3S)-2-methoxytetrahydrofuran-3-yl]-L-leucinamide (intermediate 1.8). The reaction product is purified by chromatography on silica (eluent: ethyl acetate/heptane in proportions of 7/3 to 1/1). 228 mg of a yellow solid is obtained with a yield of 21%. Melting point: 164-165° C.

WORKUP

后处理

customThe reaction product is purified by chromatography on silica (eluent: ethyl acetate/heptane in proportions of 7/3 to 1/1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-152e200e3f76433e945e2f5c76c215f4
来源数据集: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07384933B2
来源说明: uspto-grants-2008_06

反应 SMILES

[CH:1]1[C:14]2[NH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[S:6][C:5]=2[CH:4]=[CH:3][C:2]=1[C:15]([OH:17])=O.[NH2:18][C@H:19]([C:24]([NH:26][C@H:27]([C:32]([NH:34][C@H:35]([C:40]([NH:42][C@H:43]1[CH2:47][CH2:46][O:45][CH:44]1[O:48][CH3:49])=[O:41])[CH2:36][CH:37]([CH3:39])[CH3:38])=[O:33])[CH2:28][CH:29]([CH3:31])[CH3:30])=[O:25])[CH2:20][CH:21]([CH3:23])[CH3:22]>>[CH:1]1[C:14]2[NH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[S:6][C:5]=2[CH:4]=[CH:3][C:2]=1[C:15]([NH:18][C@H:19]([C:24]([NH:26][C@H:27]([C:32]([NH:34][C@H:35]([C:40]([NH:42][C@H:43]1[CH2:47][CH2:46][O:45][CH:44]1[O:48][CH3:49])=[O:41])[CH2:36][CH:37]([CH3:38])[CH3:39])=[O:33])[CH2:28][CH:29]([CH3:31])[CH3:30])=[O:25])[CH2:20][CH:21]([CH3:23])[CH3:22])=[O:17]