反应详情

Following the procedures of Example 3, except using m-anisoyl chloride, (S)-2-amino-4-cyclohexyl-butyric acid, ethanolamine and 5-methoxyindoline as starting materials, the title compound was prepared in 20% yield. The final material was purified by reverse phase preparative HPLC using TFA as a modifier. The final compound is therefore a partial TFA salt and the properties are reported for the material as it appeared after solvent removal: 1H NMR (CDCl3, 400 MHz) δ 0.58-0.72 (m, 2H), 0.85-1.10 (m, 6H), 1.37-1.59 (m, 6H), 1.62-1.73 (m, 1H), 2.54-2.67 (m, 2H), 2.85-2.98 (m, 2H), 3.20-3.33 (m, 2H), 3.41 (s, 3H), 3.55-3.70 (m, 2H), 3.64 (s, 3H), 4.34 (dd, 1H, J1=7.1, J2=13.9), 6.72-6.78 (m, 2H), 6.84-6.90 (m, 2H), 7.06-7.19 (m, 5H); HPLC-MS calcd. for C29H39N3O4 (M+H+) 494.3, found 494.5.

1. customThe final material was purified by reverse phase preparative HPLC
2. customafter solvent removal