反应详情

1 ml of fuming nitric acid was added to 57 mg of N-(4-(3-((t-butyl(dimethyl)silyl)oxy)pyrrolidin-2-yl)-3-fluorophenyl)pyridine-2-carboxamide, and the reaction liquid was stirred at room temperature for 40 minutes. The reaction liquid was poured into a mixed solution of ice-aqueous saturated sodium bicarbonate, extracted with chloroform, and dried with anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure, and the resulting residue was purified through partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), chloroform/methanol=20/1) to obtain diastereomer A and diastereomer B of the entitled compound each as a yellow oily substance.

1. customthe reaction liquid
2. customThe reaction liquid
3. additionwas poured into a mixed solution of ice-aqueous saturated sodium bicarbonate
4. extractionextracted with chloroform
5. dry with materialdried with anhydrous sodium sulfate
6. customThe solvent was evaporated away under reduced pressure
7. customthe resulting residue was purified
8. customthrough partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), chloroform/methanol=20/1)
9. customto obtain diastereomer A and diastereomer B of the entitled compound each as a yellow oily substance