反应详情

7.46 ml of tetrabutylammonium fluoride (1 M tetrahydrofuran solution) was added to a tetrahydrofuran (30 ml) solution of 2.04 g of benzyl (2R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-2-(methoxy-methyl-carbamoyl)-pyrrolidine-1-carboxylate obtained in (step 2), and the reaction liquid was stirred at room temperature for 20 minutes. The solvent of the reaction liquid was evaporated away under reduced pressure, and the resulting residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=1/3) to obtain the entitled compound.

1. customobtained in (step 2)
2. customthe reaction liquid
3. customThe solvent of the reaction liquid
4. customwas evaporated away under reduced pressure
5. customthe resulting residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=1/3)
6. customto obtain the entitled compound