反应详情

温度

0 °C

The crude crystals (1.0 g) of tert-butyl [1-(3,4-dichlorobenzylcarbamoyl)-1-methylethyl]carbamate obtained in the previous step was dissolved in tetrahydrofuran (5 ml) and cooled to 0° C. under an argon atmosphere. A borane-tetrahydrofuran complex (1.0 M/tetrahydrofuran solution) (15 ml) was added dropwise at the same temperature, removed from an ice-bath and stirred at room temperature for 2 hr. A borane-tetrahydrofuran complex (1.0 M/tetrahydrofuran solution) (5 ml) was added every 30 minutes twice in total. To the obtained reaction mixture was added methanol (10 ml) under ice-cooling, and the solvent was evaporated. The obtained residue was dissolved in tetrahydrofuran (10 ml) and 1N aqueous sodium hydroxide solution (4 ml) and the mixture was stirred at 90° C. for 1 hr. The obtained reaction mixture was extracted twice with toluene, and the combined organic layer was washed with saturated brine and dried over sodium sulfate. The solvent was evaporated and the obtained residue was purified by silica-gel column chromatography (hexane:ethyl acetate=l:l) to give tert-butyl[2-(3,4-dichlorobenzylamino)-1,1-dimethylethyl]carbamate (290 mg).

1. customremoved from an ice-bath
2. additionA borane-tetrahydrofuran complex (1.0 M/tetrahydrofuran solution) (5 ml) was added every 30 minutes twice in total
3. customTo the obtained reaction mixture
4. temperaturecooling
5. customthe solvent was evaporated
6. dissolutionThe obtained residue was dissolved in tetrahydrofuran (10 ml)
7. stirring1N aqueous sodium hydroxide solution (4 ml) and the mixture was stirred at 90° C. for 1 hr
8. customThe obtained reaction mixture
9. extractionwas extracted twice with toluene
10. washthe combined organic layer was washed with saturated brine
11. dry with materialdried over sodium sulfate
12. customThe solvent was evaporated
13. customthe obtained residue was purified by silica-gel column chromatography (hexane:ethyl acetate=l:l)