HRID1350613

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID178418361

未命名化合物

结构：CCCC[C@H]1CC[C@H]([C@H]2CC[C@H](/C=C/c3cc4ccc(OCC)c(F)c4c(F)c3F)CC2)CC1

HCID178445628

未命名化合物

PRODUCTS

生成物

结构：CCCC[C@H]1CC[C@H]([C@H]2CC[C@H](c3ccccc3-c3cc4ccc(OCC)c(F)c4c(F)c3F)CC2)CC1

HCID178445627

未命名化合物

收率 98%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID178418390

未命名化合物

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

The crude production of (E)-7-ethoxy-3-[2-[trans-4-(trans-4-butylcyclohexyl)cyclohexyl]ethenyl]-1,2,8-trifluoronaphthalene (16.6 g), 5% palladium-carbon (with 10% moisture) (3.1 g), tetrahydrofuran (100 ml) were added in an autoclave and reacted for 4 hours at room temperature under 4 atm of hydrogen. The reaction solution was filtrated with celite, and the filtrate was concentrated. Then, 7-ethoxy-3-[2-[trans-4-(trans-4-butylcyclohexyl)cyclohexyl]phenyl]-1,2,8-trifluoronaphthalene (9 g) was obtained.

WORKUP

后处理

filtrationThe reaction solution was filtrated with celite
concentrationthe filtrate was concentrated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1bc6c8a706b9420990be43887c96894d
来源数据集: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07214835B2
来源说明: uspto-grants-2007_05

反应 SMILES

[CH2:1]([O:3][C:4]1[C:13]([F:14])=[C:12]2[C:7]([CH:8]=[C:9](/[CH:17]=[CH:18]/[C@H:19]3[CH2:24][CH2:23][C@H:22]([C@H:25]4[CH2:30][CH2:29][C@H:28]([CH2:31][CH2:32][CH2:33][CH3:34])[CH2:27][CH2:26]4)[CH2:21][CH2:20]3)[C:10]([F:16])=[C:11]2[F:15])=[CH:6][CH:5]=1)[CH3:2].[H][H]>[C].[Pd].O1CCCC1>[CH2:1]([O:3][C:4]1[C:13]([F:14])=[C:12]2[C:7]([CH:8]=[C:9]([C:17]3[CH:6]=[CH:5][CH:4]=[CH:13][C:18]=3[C@H:19]3[CH2:24][CH2:23][C@H:22]([C@H:25]4[CH2:26][CH2:27][C@H:28]([CH2:31][CH2:32][CH2:33][CH3:34])[CH2:29][CH2:30]4)[CH2:21][CH2:20]3)[C:10]([F:16])=[C:11]2[F:15])=[CH:6][CH:5]=1)[CH3:2]