反应详情

温度

85 °C

A 2 L three-necked flask was equipped with a magnetic stirrer, a thermometer and a reflux condenser. The flask was charged with a solution of 4-(4-cyanophenyl)butyl toluenesulphonate (72 g, 0.218 mol, see step (iii) above) in dimethylformamide (0.55 L). tert-Butyl 9-oxa-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate hydrochloride (48.2, 0.182 mol, see Preparation B(I)(iv) above) was added, followed by potassium carbonate (62.9 g, 0.455 mol). The heterogeneous mixture was stirred for 22 hours at 85° C. TLC analysis indicated complete consumption of starting material. The reaction mixture was cooled to room temperature and diluted with water (0.5 L). The mixture was extracted with ethyl acetate (3×0.4 L) and the organic fractions were combined. After washing with Water (2×200 mL) and brine (200 mL), the organic layer was dried with magnesium sulfate, filtered and concentrated under vacuum. The crude brown oil was purified by chromatography on silica gel, eluting with 3:2 hexanes/ethyl acetate affording 34 g (48% yield) of sub-title compound as an off-white solid.

1. customA 2 L three-necked flask was equipped with a magnetic stirrer
2. customconsumption of starting material
3. temperatureThe reaction mixture was cooled to room temperature
4. additiondiluted with water (0.5 L)
5. extractionThe mixture was extracted with ethyl acetate (3×0.4 L)
6. washAfter washing with Water (2×200 mL) and brine (200 mL)
7. dry with materialthe organic layer was dried with magnesium sulfate
8. filtrationfiltered
9. concentrationconcentrated under vacuum
10. customThe crude brown oil was purified by chromatography on silica gel