反应详情

To a flask was added 2-pyridyl thiourea (5-1) (3.48 g, 22.7 mmol), 3 mL ethanol, and 50% by weight chloroacetaldehyde (14.4 mL, 113.5 mol). The flask was then heated to reflux. As the mixture was heated, the urea slowly dissolved in solution. After 3 hours, the ethanol was removed under reduced pressure. Saturated aqueous NaHCO3 was then added to the flask and a white precipitate formed after vigorous bubbling. The precipitate was filtered and washed with water. The white solid was then dried under vacuum overnight with P2O5 drying agent. 1H NMR (CDCl3): δ 10.95 (bs, 1H), 8.37 (d, 1H, J=4.2 Hz), 7.61 (t, 1H, J=7.0 Hz), 7.49 (d, 1H, J=3.5 Hz), 6.94 (d, 1H, J=8.3 Hz), 6.88 (t, 1H, J=7.1 Hz), 6.85 (d, 1H, J=3.7 Hz).

1. temperatureThe flask was then heated to reflux
2. temperatureAs the mixture was heated
3. customthe ethanol was removed under reduced pressure
4. additionSaturated aqueous NaHCO3 was then added to the flask
5. customa white precipitate formed after vigorous bubbling
6. filtrationThe precipitate was filtered
7. washwashed with water
8. dry with materialThe white solid was then dried under vacuum overnight with P2O5 drying agent