反应详情

温度

0 °C

2-Chloro-isonicotinic acid (12-1, 5.15 g, 32.7 mmol) was stirred in 65 mL anhydrous THF under N2. The reaction (not homogeneous) was cooled to 0° C. and oxalyl chloride (2.85 mL, 32.7 mmol) was added, followed by addition of 1 drop anh DMF. Slight bubbling occurs. The reaction was allowed to warm to RT. After 4 h reaction is homogeneous and after a total of 5 h the reaction was quickly added by pipet to a solution of methylamine (7.11 g, 228 mmol) in EtOH (20 mL). The resulting solution was concentrated in vacuo and diluted with sat NaHCO3 (aq). The solution was extracted 3× with EtOAc and the organic extracts were dried over Na2SO4, filtered ands concentrated to provide the titled compound. 1H NMR (CDCl3) δ 8.50 (d, 1H, J=5.1 Hz), 7.66 (s, 1H), 7.53 (d, 1H, J=5.1 Hz), 6.36 (bs, 1H), 3.04 (d, 2H, J=5.0 Hz).

1. customThe reaction (not homogeneous)
2. customSlight bubbling
3. temperatureto warm to RT
4. customAfter 4 h reaction
5. concentrationThe resulting solution was concentrated in vacuo
6. additiondiluted with sat NaHCO3 (aq)
7. extractionThe solution was extracted 3× with EtOAc
8. dry with materialthe organic extracts were dried over Na2SO4
9. filtrationfiltered ands
10. concentrationconcentrated