反应详情

3′-Methylacetophenone (5.00 g; 37.3 mmol), N-bromosuccinimide (6.63 g; 37.3 mmol), and benzoyl peroxide (100 mg) were added to carbon tetrachloride (70 ml), and the mixture was refluxed for 1 hour. The mixture was left to cool to room temperature, and crystals that precipitated were removed by filtration. The filtrate was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=20:1), to thereby yield 3.08 g of the target compound (yield: 38.8%).

1. temperaturethe mixture was refluxed for 1 hour
2. waitThe mixture was left
3. customcrystals that precipitated
4. customwere removed by filtration
5. customThe filtrate was evaporated under reduced pressure
6. customthe residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=20:1)