Hydrochloric Acid → N-[1-(3,5-dibromo-4-methoxy-benzyl)-6-hydroxy-1,2,3,4-tetrahydro-isoquinolin-7-yl]-4-methyl-benzenesulfonamide hydrochloride

HRID 1358465노트

반응식

HRID 1358465 반응식
C(O)(=O)C(O)=O.C([O:14][C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][C:24]=1[NH:25][S:26]([C:29]1[CH:34]=[CH:33][C:32]([CH3:35])=[CH:31][CH:30]=1)(=[O:28])=[O:27])[CH:21]([CH2:36][C:37]1[CH:42]=[C:41]([Br:43])[C:40]([O:44][CH3:45])=[C:39]([Br:46])[CH:38]=1)[NH:20][CH2:19][CH2:18]2)C1C=CC=CC=1.[OH-].[Na+].C(Cl)[Cl:50].Cl>CO>[ClH:50].[Br:46][C:39]1[CH:38]=[C:37]([CH:42]=[C:41]([Br:43])[C:40]=1[O:44][CH3:45])[CH2:36][CH:21]1[C:22]2[C:17](=[CH:16][C:15]([OH:14])=[C:24]([NH:25][S:26]([C:29]3[CH:34]=[CH:33][C:32]([CH3:35])=[CH:31][CH:30]=3)(=[O:28])=[O:27])[CH:23]=2)[CH2:18][CH2:19][NH:20]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 18184543N-[6-benzyloxy-1-(3,5-dibromo-4-methoxy-benzyl)-1,2,3,4-tetrahydro-isoquinolin-7-yl]-4-methyl-benzenesulfonamide oxalateHCID 23721229Sodium hydroxide methylene chloride

생성물 1

HCID 18184542N-[1-(3,5-dibromo-4-methoxy-benzyl)-6-hydroxy-1,2,3,4-tetrahydro-isoquinolin-7-yl]-4-methyl-benzenesulfonamide hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

N-[6-benzyloxy-1-(3,5-dibromo-4-methoxy-benzyl)-1,2,3,4-tetrahydro-isoquinolin-7-yl]-4-methyl-benzenesulfonamide oxalate (0.48 g, 0.00062 mol) was neutralized in a mixture 1N NaOH-methylene chloride. A free base was dissolved in a methanol—conc. HCl mixture (20 mL of each). The reaction mixture was refluxed for 1 h and evaporated. A residue was crystallized from methanol—ethyl ether mixture.

후처리

  1. temperatureThe reaction mixture was refluxed for 1 h
  2. customevaporated
  3. customA residue was crystallized from methanol—ethyl ether mixture

출처 및 근거

ORD 기록
ord-5aec1e3893f64ad2b7fccc3f5218174d
출처 데이터셋
uspto-grants-2003_07
특허 번호
US06596734B1

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