反应详情

N-[6-benzyloxy-1-(3,5-dibromo-4-methoxy-benzyl)-1,2,3,4-tetrahydro-isoquinolin-7-yl]-4-methyl-benzenesulfonamide oxalate (0.48 g, 0.00062 mol) was neutralized in a mixture 1N NaOH-methylene chloride. A free base was dissolved in a methanol—conc. HCl mixture (20 mL of each). The reaction mixture was refluxed for 1 h and evaporated. A residue was crystallized from methanol—ethyl ether mixture.

1. temperatureThe reaction mixture was refluxed for 1 h
2. customevaporated
3. customA residue was crystallized from methanol—ethyl ether mixture