反应详情

To 0.326 mmoles of (4-Chloro-phenyl)-[4-(4-hydroxy-pyrrolidin-3-yl)-piperazin-1-yl]-methanone (synthesis described above in Example 5), add 1.6 mL acetonitrile and 1.63 mmoles of DBU. The stirred solution was cooled in ice and then 0.358 mmoles of 4-chloro-6-methoxy-2-trifluoromethyl-quinazoline was added and the reaction mixture was allowed to stir for a period of 2.5 hours. For the workup, the reaction mixture was diluted with methanol and concentrated on the rotavap. To the concentrate about 35 mL of water was added and was extracted with 40 mL EtOAc. The organic layer was separated and washed with 35 mL of 1M aq K2CO3 soln, and brine, dried over MgSO4 and excess solvent was removed on rotavap to yield a crude oil. This was diluted with about 2 mL EtOAc and about 8 mL ether was added and the white solid obtained was filtered off and vaccum dried to give the title compound in 80% yield. LC-MS: m/z=536 (M++1)

1. temperatureThe stirred solution was cooled in ice
2. concentrationconcentrated on the rotavap
3. additionTo the concentrate about 35 mL of water was added
4. extractionwas extracted with 40 mL EtOAc
5. customThe organic layer was separated
6. washwashed with 35 mL of 1M aq K2CO3 soln
7. dry with materialbrine, dried over MgSO4 and excess solvent
8. customwas removed on rotavap
9. customto yield a crude oil
10. additionwas added
11. customthe white solid obtained
12. filtrationwas filtered off
13. customvaccum dried