反应详情

This was prepared in an analogous manner to Intermediate 3, using 6-butyl-8-fluoroquinoline (for example, as prepared for Intermediate 2) and N-tert-butoxycarbonyl-(R)-(−)-3-pyrrolidinol (commercially available, for example, from Aldrich) instead of 1,1-dimethylethyl 4-hydroxy-1-piperidinecarboxylate. The reaction time was 3 h instead of 1.5 h. LCMS RT=3.56 min, ES+ve m/z 371 (M+H)+.