反应详情

温度

60 °C

tert-Butyl 2-[(3-amino-5,6-dimethyl-2-phenoxypyridin-4-yl)amino]ethylcarbamate (17.9 g, 48.1 mmol), prepared as described in U.S. Pat. No. 6,545,016 Example 23, Parts A through C, was dissolved in chloroform (250 mL). Ethyl 2-chloroacetimidate hydrochloride (15.2 g, 96 mmol) was added to the solution and the reaction mixture was stirred at 60° C. for 5 hours. Additional ethyl 2-chloroacetimidate hydrochloride (1.9 g) was added to the reaction mixture and stirred for 0.5 hours. The reaction mixture was cooled and filtered. The filtrate was diluted with chloroform (250 mL), washed with brine (2×300 mL), and the layers were separated. The combined organics were dried over magnesium sulfate, filtered with CELITE filter aid, and concentrated under reduced pressure. The material was recrystallized and filtered from acetonitrile to yield 13.28 g of tert-butyl 2-[2-(chloromethyl)-6,7-dimethyl-4-phenoxy-1H-imidazo[4,5-c]pyridin-1-yl]ethylcarbamate as a white solid.

1. stirringstirred for 0.5 hours
2. temperatureThe reaction mixture was cooled
3. filtrationfiltered
4. additionThe filtrate was diluted with chloroform (250 mL)
5. washwashed with brine (2×300 mL)
6. customthe layers were separated
7. dry with materialThe combined organics were dried over magnesium sulfate
8. filtrationfiltered with CELITE
9. filtrationfilter aid
10. concentrationconcentrated under reduced pressure
11. customThe material was recrystallized
12. filtrationfiltered from acetonitrile