HCID 66934470, compound → HCID 66934526, compound

HRID 1366323Notes

Reaction equation

HRID 1366323 reaction equation
C([O:5][C:6](=[O:40])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C@@H:15]2[C@@H:18]([S:19][CH2:20][C:21]([C:23]3[CH:31]=[CH:30][C:26]4[CH2:27][CH2:28][O:29][C:25]=4[CH:24]=3)=[O:22])[C:17](=[O:32])[N:16]2[C:33]2[CH:38]=[CH:37][C:36]([F:39])=[CH:35][CH:34]=2)=[CH:11][CH:10]=1)(C)(C)C>C(O)=O>[O:29]1[C:25]2[CH:24]=[C:23]([C:21](=[O:22])[CH2:20][S:19][C@H:18]3[C:17](=[O:32])[N:16]([C:33]4[CH:34]=[CH:35][C:36]([F:39])=[CH:37][CH:38]=4)[C@@H:15]3[C:12]3[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:40])=[O:5])=[CH:10][CH:11]=3)[CH:31]=[CH:30][C:26]=2[CH2:27][CH2:28]1

Participants

3

Reactant 1

HCID 66934470HCID 66934470, compound

Product 1

HCID 66934526HCID 66934526, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

{4-[(2R,3R)-3-[2-(2,3-Dihydro-benzofuran-6-yl)-2-oxo-ethylsulfanyl]1-(4-fluoro-phenyl)-4-oxo-azetidin-2-yl]-phenoxy}-acetic acid tert-butyl ester (77 mg, 0.137 mmol) was dissolved in formic acid (3 mL) and the solution was stirred for 1 h at room temperature. The solvent was removed under reduced pressure and the residue was dissolved in DCM. The solution was washed with water and then concentrated under reduced pressure. The residue was freeze-dried from MeCN/water to give the title compound.

Workup

  1. customThe solvent was removed under reduced pressure
  2. dissolutionthe residue was dissolved in DCM
  3. washThe solution was washed with water
  4. concentrationconcentrated under reduced pressure
  5. dry with materialThe residue was freeze-dried from MeCN/water

Sources & evidence

ORD record
ord-e2146da7156e47beb727fe6f652a921e
Source dataset
uspto-grants-2011_02
Patent number
US07893048B2

Reaction notes

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