反应详情

温度

50 °C

Production of [5-[1-(tert-Butyldimethylsilyloxy)-ethyl]-6-methoxynaphthalen-2-yl]-(1H-imidazol-4-yl)ketone. [5-[1-(tert-butyldimethylsilyloxy)ethyl]-6-methoxynaphthalen-2-yl]-(1-trityl-1H-imidazol-4-yl)ketone (5.18 g) and pyridine hydrochloride (1.59 g) were dissolved in methanol (50 ml). The solution was stirred at 50° C. for 1 h. The reaction mixture was concentrated, and water and ethyl acetate were added. The organic layer was washed with saturated aqueous solution of sodium hydrogencarbonate and saturated sodium chloride solution, dried and concentrated. The obtained residue was washed with ether to give the titled compound (2.71 g) as a colorless solid.

1. concentrationThe reaction mixture was concentrated
2. additionwater and ethyl acetate were added
3. washThe organic layer was washed with saturated aqueous solution of sodium hydrogencarbonate and saturated sodium chloride solution
4. customdried
5. concentrationconcentrated
6. washThe obtained residue was washed with ether