反应详情

An aqueous solution of sodium hydroxyde (2N, 1 ml) was slowly added to a solution of ethyl 2-{4-[([4-(1,3-benzodioxol-5-yl)-3-(cyclopropylmethoxy)-1-methyl-1H-pyrazol-5-yl]amino)sulfonyl]phenyl}-2-methylpropanoate (Example 75) (83 mg) in a mixture of methanol:water:tetrahydrofuran (1:1:1) (6 ml) and the reaction was heated to 50 C. for 24 h. The reaction was quenched by the addition of a saturated aqueous solution of ammonium chloride (8 ml) and extracted with dichloromethane (3×8 ml). The organic fraction was dried over sodium sulfate and concentrated under reduced pressure. The residue was purified by preparative TLC eluted with dichloromethane:methanol (9:1) yielding the title compound as a white solid (28.8 mg).

1. temperaturethe reaction was heated to 50 C
2. customThe reaction was quenched by the addition of a saturated aqueous solution of ammonium chloride (8 ml)
3. extractionextracted with dichloromethane (3×8 ml)
4. dry with materialThe organic fraction was dried over sodium sulfate
5. concentrationconcentrated under reduced pressure
6. customThe residue was purified by preparative TLC
7. washeluted with dichloromethane:methanol (9:1)