HRID1369092

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCN(CC)CCN1C(=O)C(O)(c2ccccc2Cl)c2c1cc(I)cc2C(F)(F)F

HCID12990216

未命名化合物

HCID13765095

未命名化合物

PRODUCTS

生成物

结构：CCN(CC)CCN1C(=O)C(O)(c2ccccc2Cl)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F

HCID11146604

未命名化合物

PROCEDURE

实验过程

The title compound (246 mg) was prepared from (+)-1-(2-diethylaminoethyl)-4-trifluoromethyl-6-iodo-3-hydroxy-3-(2-chlorophenyl)oxindole (300 mg, 0.543 mmol) and 4-morpholinocarbonyl-1-butyne by the procedure similar to that described in Reference Example 21. The hydrochloride of the title compound was obtained by treating with 4 N HCl in dioxane followed by concentration to dryness. The NMR spectra of the title compound exhibited the same as in Example 70. [α]D +58.3° (c=0.252, MeOH).

WORKUP

后处理

customThe hydrochloride of the title compound was obtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-021c453bd0574486805fb7b71009be3c
来源数据集: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06576656B1
来源说明: uspto-grants-2003_06

反应 SMILES

[CH2:1]([N:3]([CH2:29][CH3:30])[CH2:4][CH2:5][N:6]1[C:14]2[C:9](=[C:10]([C:16]([F:19])([F:18])[F:17])[CH:11]=[C:12](I)[CH:13]=2)[C:8]([OH:27])([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[Cl:26])[C:7]1=[O:28])[CH3:2].[O:31]1[CH2:36][CH2:35][N:34]([C:37]([CH2:39][CH2:40][C:41]#[CH:42])=[O:38])[CH2:33][CH2:32]1>>[CH2:1]([N:3]([CH2:29][CH3:30])[CH2:4][CH2:5][N:6]1[C:14]2[C:9](=[C:10]([C:16]([F:19])([F:18])[F:17])[CH:11]=[C:12]([C:42]#[C:41][CH2:40][CH2:39][C:37]([N:34]3[CH2:35][CH2:36][O:31][CH2:32][CH2:33]3)=[O:38])[CH:13]=2)[C:8]([OH:27])([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[Cl:26])[C:7]1=[O:28])[CH3:2]