反应详情

To a solution of methyl (2S,4S)-1-tert-butoxycarbonyl-4-(2-naphthyloxy)-2-pyrrolidinylcarboxylate (5.37 g) in THF (116 ml) was added 0.25N NaOH (116 ml, 29.0 mmol). The resulting mixture was stirred overnight at room temperature. The reaction mixture was concentrated under reduced pressure. The residue was acidified with 1N HCl, followed by extraction with chloroform. The extract was washed with saturated brine, dried over anhydrous sodium sulfate and distilled under reduced pressure to remove the solvent. The residue thus obtained was recrystallized from hexane-chloroform, whereby the title compound (4.44 g, 85% (2 steps)) was obtained as white crystalline powder.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. extractionfollowed by extraction with chloroform
3. washThe extract was washed with saturated brine
4. dry with materialdried over anhydrous sodium sulfate
5. distillationdistilled under reduced pressure
6. customto remove the solvent
7. customThe residue thus obtained
8. customwas recrystallized from hexane-chloroform, whereby the title compound (4.44 g, 85% (2 steps))
9. customwas obtained as white crystalline powder