Acetic Anhydride → 5-Acetyl-3-amino-1,3,4,5-tetrahydro-benzo[b][1,4]diazepin-2-one
Reaction equation
C(OC(=O)[NH:7][C@@H:8]1[C:14](=[O:15])[NH:13][C:12]2[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=2[NH:10][CH2:9]1)(C)(C)C.[C:21](OC(=O)C)(=[O:23])[CH3:22]>>[C:21]([N:10]1[CH2:9][CH:8]([NH2:7])[C:14](=[O:15])[NH:13][C:12]2[CH:16]=[CH:17][CH:18]=[CH:19][C:11]1=2)(=[O:23])[CH3:22]Participants
Procedure
A solution of 0.5 g (1.8 mmol) (S)-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-carbamic acid tert-butyl ester in 1.7 ml of acetic anhydride is stirred for 3 hours at 65° C. The mixture was put onto water (5 ml) and extracted two times with dichloromethane (10 ml each). The combined organic layers were dried (MgSO4) and evaporated to yield 0.6 g of a light yellow foam. This compound was dissolved in a mixture of 2 ml of dichlorometane and 2 ml of trifluoracetic acid and stirred for 2.5 h at room temperature. For workup the mixture was concentrated in vacuo, then dichloromethane was added and the mixture was extracted with sodium bicarbonate solution. The organic phase was dried (MgSO4) and evaporated to yield 0.31 g of (S)-1-acetyl-3-amino-1,3,4,5-tetrahydro-benzo[b][1,4]diazepin-2-one as a light yellow solid.
Workup
- extractionextracted two times with dichloromethane (10 ml each)
- dry with materialThe combined organic layers were dried (MgSO4)
- customevaporated
Sources & evidence
- ORD record
- ord-0bd887b1192345b8b1bf26359cd15cf1
- Source dataset
- uspto-grants-2007_01
- Patent number
- US07160875B2
Reaction notes
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