反应详情

7-Chloro-2-(4-fluorophenyl)-3-(4-pyridinyl)pyrazolo[1,5-α]pyridine (25 mg, 0.077 mmol) and excess of methylamine in alcohol (1 mL) in sealed tube was heated at 120° C. for overnight. The mixture was evaporated to dryness and purified by preparative thin layer chromatography to give 2-(4-fluorophenyl)-N-methyl-3-(4-pyridinyl)pyrazolo[1,5-α]pyridin-7-amine a peach solid in 77.3% yield. 1H NMR (CDCl3): δ 8.59 (d, 2H, J=5.4 Hz), 7.58–7.62 (m, 2H), 7.28–7.30 (m, 3H), 7.07–7.14 (m, 3H), 6.11 (bs, 1H), 6.00 (d, 1H, J=7.4 Hz), 3.16 (d, 3H, J=5.0 Hz); MS (ES+ve): 320 (18, M+2), 319 (20, M+1), 318 (100, M+).

1. customThe mixture was evaporated to dryness
2. custompurified by preparative thin layer chromatography