反应详情

A suspension of tert-butyl N′-(7-bromo-3-nitroquinolin-4-yl)hydrazinecarboxylate (50.0 g, 131 mmol) in 320 mL of acetonitrile (MeCN) and 80 mL of methanol was treated with platinum on carbon (5.0 g, 1.3 mmol, 5% w/w) and shaken under an atmosphere of hydrogen (3.8×105 Pa). After 4 h, the reaction mixture was filtered through a pad of CELITE filter agent and rinsed with portions of MeCN:MeOH (1:1) until the filtrate ran clear. The filtrate was concentrated under reduced pressure to yield 37.1 g of tert-butyl N′-(3-amino-7-bromoquinolin-4-yl)hydrazinecarboxylate as a tan solid.

1. filtrationthe reaction mixture was filtered through a pad of CELITE
2. filtrationfilter agent
3. washrinsed with portions of MeCN:MeOH (1:1) until the filtrate
4. concentrationThe filtrate was concentrated under reduced pressure