反应详情

tert-Butyl 9-oxa-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate (1.35 g, 5.9 mmol, see Preparation A and Preparation C(iii) above) was mixed with 4-(4-chlorobutyl)pyridine (1.35 g, 7.37 mmol, see Example 10(i) above), Br2 (0.094 g, 0.59 mmol ) and K2CO3 (3.26 g, 23.6 mmol). The mixture was refluxed under argon for 3 days. The reaction mixture was filtered, evaporated and purified by chromatography (DCM, 2–5% MeOH) giving 0.97 g (44%) of the sub-title compound.

1. temperatureThe mixture was refluxed under argon for 3 days
2. filtrationThe reaction mixture was filtered
3. customevaporated
4. custompurified by chromatography (DCM, 2–5% MeOH)