反应详情

A solution of 1-[3,5-bis(trifluoromethyl)benzoyl]-4-(benzyloxycarbonyl)-2-[3-[(2-methoxyethoxy)methoxy]-4-methylbenzyl]piperazine (1.6 g) in methanol (20 ml) was hydrogenated over 10% palladium-carbon (50% wet, 0.2 g) at room temperature under atmospheric pressure for 4 hours. After removal of the catalyst by filtration, the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel using mixed solvents of dichloromethane and methanol (40:1). The fractions containing the objective compound were collected and evaporated under reduced pressure to give 1-[3,5-bis(trifluoromethyl)benzoyl]-2-[3-[(2-methoxyethoxy)methoxy]-4-methylbenzyl]piperazine (0.89 g) as an oil.

1. customAfter removal of the catalyst
2. filtrationby filtration
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe residue was purified by column chromatography on silica gel using
5. additionmixed solvents of dichloromethane and methanol (40:1)
6. additionThe fractions containing the objective compound
7. customwere collected
8. customevaporated under reduced pressure