反应详情

To 4[-2-Amino-1-(2-chloro-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester (201) (2.15 g, 6.34 mmol) in DMF (15 mL) was added K2CO3 (4.38 g , 31.71 mmol) and ethyl bromide (2.07 g, 19.03 mmol). The reaction mixture was allowed to stir at room temperature for 18 h. The reaction mixture was diluted with EtOAc (100 mL) and washed with H2O (100 mL) The organic phase was concentrated to dryness. The crude material was purified by chromatography (silica gel 60 mesh, eluting with 5% MeOH in CHC13) yielding 1.55 g (62%) pure product.

1. washwashed with H2O (100 mL) The organic phase
2. concentrationwas concentrated to dryness
3. customThe crude material was purified by chromatography (silica gel 60 mesh, eluting with 5% MeOH in CHC13)