HCID 15524163, compound → Methyl 2-[({4-[1-(t-butoxycarbonyl)propyl]benzenesulfonylamino}carbonyl)amino]-4-chlorobenzoate
Reaction equation
[NH2:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]([CH2:19][CH3:20])[C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[Cl:21][C:22]1[CH:23]=[C:24]([NH:32][C:33](OC2C=CC=CC=2)=[O:34])[C:25](=[CH:30][CH:31]=1)[C:26]([O:28][CH3:29])=[O:27]>>[C:15]([O:14][C:12]([CH:11]([C:8]1[CH:7]=[CH:6][C:5]([S:2]([NH:1][C:33]([NH:32][C:24]2[CH:23]=[C:22]([Cl:21])[CH:31]=[CH:30][C:25]=2[C:26]([O:28][CH3:29])=[O:27])=[O:34])(=[O:3])=[O:4])=[CH:10][CH:9]=1)[CH2:19][CH3:20])=[O:13])([CH3:16])([CH3:18])[CH3:17]Participants
3
Procedure
1.02 g (3.41 mmol) of t-butyl (±)-2-(4-aminosulfonylphenyl)butyrate acid and 1.04 g (3.41 mmol) of methyl 4-chloro-2-N-phenoxycarbonylanthranilate were treated in the same way as Example 1 to obtain 1.46 g (yield 84%) of methyl 2-[({4-[1-(t-butoxycarbonyl)propyl]benzenesulfonylamino}carbonyl)amino]-4-chlorobenzoate. Properties: colorless amorphous, PMR (δ ppm, CDCl3):0.89 (3H, t), 1.38 (9H, s), 1.69–1.76 (1H, m), 2.03–2.10 (1H, m), 3.42 (1H, t), 3.94 (3H, s), 7.04 (1H, d), 7.47 (2H, d), 7.93 (1H, d), 8.01 (2H, d), 8.45 (1H, br), 11.04 (1H, br).
Sources & evidence
- ORD record
- ord-013da416a946434c94b6cd2dc3787fa7
- Source dataset
- uspto-grants-2007_01
- Patent number
- US07169951B2
Reaction notes
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