反应详情

To a solution of 394 mg (1.49 mmol) of the above-obtained 5-(N-methyl-N-trifluoroacetylamino)methylimidazo[5,1-b]thiazole in 3 ml of methanol was added 3 ml of a 10% aqueous solution of sodium hydroxide, and the mixture was stirred at room temperature for 1 hour. The methanol was distilled off under reduced pressure. The resultant was extracted three times with chloroform. The organic layer was dried over anhydrous potassium carbonate, and concentrated under reduced pressure to give 272 mg of the title compound as an oil.

1. distillationThe methanol was distilled off under reduced pressure
2. extractionThe resultant was extracted three times with chloroform
3. dry with materialThe organic layer was dried over anhydrous potassium carbonate
4. concentrationconcentrated under reduced pressure