反应详情

1.28 g (3.06 mmol) of 7-chloro-3-(5-diethylaminomethyl-1,2,4-oxadiazol-3-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one in 20 ml of ethanol were treated with 0.91 ml (3.36 mmol) of 3.7N ethanolic hydrochloric acid. After stirring at room temperature for 10 minutes the white suspension obtained was treated with 100 ml of ether and suction filtered. There were obtained 1.31 g (94%) of 7-chloro-3-(5-diethylaminomethyl-1,2,4-oxadiazol-3-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-6-one hydrochloride (1:1) as white crystals; m.p. 206°-209° (dec.).

1. customobtained
2. filtrationfiltered