反应详情

1.2 g of 2-(2-chloroethyl)-2,3-dihydro-1H-benz[de]isoquinoline-1,3-dione ("A") [obtainable by reaction of 2,3-dihydro-1H-benz[de]isoquinoline-1,3-dione with 1,2-dichloroethane to give 2-(2-chloroethyl)-2,3-dihydro-1H-benz[de]isoquinoline-1,3-dione] and 1.0 g of 4-(5-fluoroindol-3-yl)piperidine [obtainable by reaction of N-BOC-4-chloropiperidine with 5-fluoroindole and subsequent removal of the protective group] are dissolved in 200 ml of acetonitrile and the mixture is stirred at room temperature for 8 hours. Customary working up gives 2-[2-(4-(5-fluoro-3-indolyl)piperidino)ethyl]-2,3-dihydro-1H-benz[de]isoquinoline-1,3-dione, tetrahydrate, m.p. 235°.

1. customwith 5-fluoroindole and subsequent removal of the protective group]
2. dissolutionare dissolved in 200 ml of acetonitrile