HRID1379876

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)NC(C)(C)C(=O)N[C@@H]1CCc2ccccc2NC1=O

HCID10808566

未命名化合物

HCID21836805

未命名化合物

PRODUCTS

生成物

结构：CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)NC(=O)OC(C)(C)C)CCc3ccccc32)c(Br)c1

HCID67553623

未命名化合物

PROCEDURE

实验过程

Prepared from 2-t-butoxycarbonylamino-2-methyl- N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]propanamide (Step K) and 2'-[[(methylamino)carbonyl]amino]methyl-3-bromo-1,1'-biphenyl-4-methanol, methanesulfonate ester (Step J) according to the procedure described in Example 35, Step H. 1H NMR (200 MHz, CDCl3): δ 1.39 (s, 12H), 1.41 (s, 3H), 1.92 (m, 1H), 2.48-2.75 (m, 6H), 4.20 (d, 6 Hz, 2H), 4.52 (m, 2H), 4.70 (m, 1H), 4.92 (m, 2H), 7.08-7.35 (m, 10H) 7.42 (m, 1H).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fb5152199e964d2caf5b2dd1675a1a3b
来源数据集: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05672596
来源说明: uspto-grants-1997_09

反应 SMILES

[C:1]([O:5][C:6]([NH:8][C:9]([CH3:26])([CH3:25])[C:10]([NH:12][C@@H:13]1[CH2:19][CH2:18][C:17]2[CH:20]=[CH:21][CH:22]=[CH:23][C:16]=2[NH:15][C:14]1=[O:24])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:27][NH:28][C:29]([NH:31][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=1[C:39]1[CH:44]=[CH:43][C:42]([CH2:45]O)=[C:41]([Br:47])[CH:40]=1)=[O:30]>>[C:1]([O:5][C:6]([NH:8][C:9]([CH3:26])([CH3:25])[C:10]([NH:12][C@@H:13]1[CH2:19][CH2:18][C:17]2[CH:20]=[CH:21][CH:22]=[CH:23][C:16]=2[N:15]([CH2:45][C:42]2[CH:43]=[CH:44][C:39]([C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=3[CH2:32][NH:31][C:29]([NH:28][CH3:27])=[O:30])=[CH:40][C:41]=2[Br:47])[C:14]1=[O:24])=[O:11])=[O:7])([CH3:4])([CH3:2])[CH3:3]