反应详情

10.84 g of 8-benzyloxy-5-(dihydroxyacetyl)carbostyril 1/3 hydrate and 5.66 g of N-(2-(p-methoxyphenyl)-1-methylethyl)amine are dissolved in 100 ml of dimethylsulfoxide, and the solution is stirred at room temperature for one hour. The mixture is extracted with chloroform, and the extract is washed with water and a saturated sodium chloride solution, successively. The chloroform solution is dried and concentrated under reduced pressure to remove solvent. The residue is crystallized with a mixture of ethyl acetate and n-hexane, and crystalline precipitates are collected by filtration. 13 g of 8-benzyloxy-5-{1-oxo-2-[N-(2-(p-methoxyphenyl)-1-methylethyl)imino]ethyl}carbostyril are obtained as yellow solid. Yield: 87.6%

1. extractionThe mixture is extracted with chloroform
2. washthe extract is washed with water
3. dry with materialThe chloroform solution is dried
4. concentrationconcentrated under reduced pressure
5. customto remove solvent
6. customThe residue is crystallized with a mixture of ethyl acetate and n-hexane
7. customcrystalline precipitates
8. filtrationare collected by filtration