反应详情

5-Bromo-2-(4-aminobutyl)-3-methylpyridine (2.12 g) and 2-nitroamino-5-(6-methylpyrid-3-ylmethyl)-4-pyrimidone (3.18 g) were refluxed in pyridine (12 ml) for 9.5 hrs. The pyridine was removed in vacuo and the residue was re-evaporated with n-propanol (2×50 ml), triturated with chloroform, filtered and the solution was chromatographed on silica in chloroform-methanol (10:1). The product was crystallised from ethanol-ether to give 2-[4-(5-bromo-3-methylpyrid-2-yl)-butylamino]-5-(6-methylpyrid-3-yl-methyl)-4-pyrimidone (2.44 g) m.p. 151°-152° C.

1. customThe pyridine was removed in vacuo
2. customthe residue was re-evaporated with n-propanol (2×50 ml)
3. customtriturated with chloroform
4. filtrationfiltered
5. customthe solution was chromatographed on silica in chloroform-methanol (10:1)
6. customThe product was crystallised from ethanol-ether