反应详情

2-Ethoxy-3-{4-[2-(4-methanesulfonyloxyphenyl)ethoxy]phenyl}acrylic acid ethyl ester (1.47 g; 3.38 mmole) was hydrogenated for 3 hours at atmospheric pressure in ethyl acetate (50 ml) using Pd/C (5%; 0.75 g) as catalyst. The reaction mixture was filtered through celite and dried (magnesium sulfate). The solvent was evaporated in vacuo to give (1.44 g; yield 98%) of 2-ethoxy-3-[4(2-{4-methanesulfonyloxyphenyl}-ethoxy)phenyl]propanoic acid ethyl ester.

1. filtrationThe reaction mixture was filtered through celite
2. dry with materialdried (magnesium sulfate)
3. customThe solvent was evaporated in vacuo