反应详情

Using a procedure analogous to that described for the starting material in Example 46, 4-chloropyridine (885 mg, 59 mmol) and 3-(methylamino)propanol (2.1 g, 0.23 mmol), (Tetrahedron Lett. 1994, 35, 1545-1548), were heated for 8 hours to give 3-(N-methyl-N-(4-pyridyl)amino)propanol (979 mg, 61%). 1H NMR Spectrum: (CDCl3; CD3COOD) 1.8-1.9(m, 2H); 3.16(s, 3H); 3.6-3.75(m, 4H) 6.8(br s, 2H); 8.30(d, 2H) MS-ESI: 166 [MH]+

1. temperaturewere heated for 8 hours