反应详情

To a solution containing 0.52 g (2.7 mmol) of N-methyl-2-(2,5-dimethylphenoxy)-1-methylethylamine (Example 45) in 15 ml of tetrahydrofuran 0.63 g (2.7 mmol) of 4-methanesulfonamido-phenylacetic acid (Example 32) and 0.63 g (3.05 mmol) of dicyclohexylcarbodiimide are added and the reaction mixture is stirred at room temperature for 16 hours. After filtration of the mixture, the filtrate is evaporated under reduced pressure and the pale yellowish resin of about 4.5 g obtained is purified by column chromatography by using a mixture of ethyl acetate and hexane as eluent. Thus, 0.76 g (70%) of the title compound is obtained as an amorphous material.

1. additionare added
2. filtrationAfter filtration of the mixture
3. customthe filtrate is evaporated under reduced pressure
4. customthe pale yellowish resin of about 4.5 g obtained
5. customis purified by column chromatography
6. additiona mixture of ethyl acetate and hexane as eluent