2-Amino-1-(1-benzofuran-2-yl)ethan-1-ol → HCID 12816505, compound

HRID 1388737Notes

Reaction equation

HRID 1388737 reaction equation
O1C2C=CC=CC=2C=C1C(O)CN.C(CCCOC1C=CC(CC(=O)C)=CC=1)(OC)=O.[C:32]([C:36]1[CH:37]=[C:38](C=CC=1)[O:39][C:40]1[CH:45]=[CH:44][C:43]([CH:46]2C=CC=[CH:48][C:47]2([NH:53][CH2:54][CH:55]([C:57]2[O:58][C:59]3[CH:65]=[CH:64][CH:63]=[CH:62][C:60]=3[CH:61]=2)[OH:56])C)=[CH:42][CH:41]=1)([O:34][CH3:35])=[O:33]>CCOCC>[C:32]([CH2:36][CH2:37][CH2:38][O:39][C:40]1[CH:45]=[CH:44][C:43]([CH2:46][CH:47]([NH:53][CH2:54][CH:55]([C:57]2[O:58][C:59]3[CH:65]=[CH:64][CH:63]=[CH:62][C:60]=3[CH:61]=2)[OH:56])[CH3:48])=[CH:42][CH:41]=1)([O:34][CH3:35])=[O:33]

Participants

5

Reactant 3

HCID 128143572-Amino-1-(1-benzofuran-2-yl)ethan-1-olHCID 130796131-(4-[3-Carbomethoxypropoxy]phenyl)propan-2-oneHCID 20470048N-[2-(4-(3-carbomethoxyphenoxy)phenyl)-1-methylphenyl]-2-(2-benzofuranyl)-2-hydroxyethanamine

Product 1

HCID 12816505HCID 12816505, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

By a method analogous to that described in Example 2 but using 2-(2-benzofuranyl)-2-hydroxyethanamine (4.54 g) and 1-(4-[3-carbomethoxypropoxy]phenyl)propan-2-one (6.41 g), N-[2-(4-(3-carbomethoxyphenoxy)phenyl)-1-methylphenyl]-2-(2-benzofuranyl)-2-hydroxyethanamine was prepared, m.p. 63°-70° (Et2O) as a 37:63 mixture of diastereoisomers.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-4ebfe79eed6743d9bbc828e9058979f1
Source dataset
uspto-grants-1984_02
Patent number
US04432993

Reaction notes

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