反应详情

5-(p-Chlorobenzoyl)-3-hydroxycarbonyl-4-methoxy-1-methylpyrrole-2-acetic acid (prepared from Example 1, Step E) is dissolved in 5 ml of trifluoroacetic acid (TFA) and heated to reflux under nitrogen. After about 45 minutes the reaction is substantially complete. It is cooled and concentrated in vacuo. The resultant residue is treated with 10 ml of water, and the precipitate is filtered, and dried to afford 925 mg (81.5%) of 5-(p-chlorobenzoyl)-4-methoxy-1-methylpyrrole-2-acetic acid, m.p. 142°.

1. temperatureheated
2. temperatureto reflux under nitrogen
3. temperatureIt is cooled
4. concentrationconcentrated in vacuo
5. additionThe resultant residue is treated with 10 ml of water
6. filtrationthe precipitate is filtered
7. customdried