反应详情

To 0.73 g of magnesium suspended in 5 ml of diethyl ether were added dropwise, under nitrogen, 8.70 g of 2-iodo-4-tert-butylanisole [described in Reference Example 1(a)] dissolved in 15 ml of diethyl ether and heated at reflux for one hour. To this solution were added dropwise 0.74 ml of trifluoroacetic acid dissolved in 3 ml of diethyl ether at room temperature, and heated at reflux for 1.5 hours. The reaction mixture was poured into ice-water, acidified with conc. sulfuric acid and extracted with diethyl ether. The extract was washed with water and saturated brine successively, dried over magnesium sulfate anhydride and concentrated at reduced pressure. The residue was chromatographed on silica gel column using a mixed solvent of methylene chloride and cyclohexane (1:2) as an eluting agent to give 1.83 g of the title compound having the following physical properties as pale yellow oil.

1. additionwere added dropwise, under nitrogen
2. temperatureheated
3. temperatureat reflux for one hour
4. temperatureheated
5. temperatureat reflux for 1.5 hours
6. extractionextracted with diethyl ether
7. washThe extract was washed with water and saturated brine successively
8. dry with materialdried over magnesium sulfate anhydride
9. concentrationconcentrated at reduced pressure
10. customThe residue was chromatographed on silica gel column