反应详情

The mixture of 4-[N-[1-[N-(benzofuran-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-(2-amino-5-fluorophenyl)piperidin-3-ol (2 g) obtained in Step 1 and 0.96 ml of 2,5-dimethoxytetrahydrofuran was refluxed for 1 hour and concentrated under reduced pressure. The resulting residue was diluted with 70 ml of dichloromethane, washed with a saturated sodium bicarbonate solution and brine. The resulting organic layer was dried and concentrated on sodium sulfate. The resulting residue was purified with column chromatography to give 1.8 g of the titled compound as white color.

1. temperaturewas refluxed for 1 hour
2. concentrationconcentrated under reduced pressure
3. additionThe resulting residue was diluted with 70 ml of dichloromethane
4. washwashed with a saturated sodium bicarbonate solution and brine
5. customThe resulting organic layer was dried
6. concentrationconcentrated on sodium sulfate
7. customThe resulting residue was purified with column chromatography