反应详情

Triethylsilane (115 mg, 0.99 mmol) was added to 5-(2,6-dibromo-4-nitro-3-trifluoromethylphenoxy)-2-hydroxy-3-isopropylbenzaldehyde of Part 11D (130 mg, 0.25 mmol) and stirred at room temperature for two minutes. TFA (6 mL) was added and the reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was concentrated and the residue was purified on column (silica gel, gradient elution with n-heptane/EtOAc) to give 133 mg (99%) of 4-(2,6-dibromo-4-nitro-3-trifluoromethylphenoxy)-2-methyl-6-isopropylphenol.

1. stirringthe reaction mixture was stirred at room temperature for 16 hours
2. concentrationThe reaction mixture was concentrated
3. customthe residue was purified on column (silica gel, gradient elution with n-heptane/EtOAc)