反应详情

4-(2-Nitro-phenyl)-thiazol-2-ylamine was prepared as follows: 2-Bromo-2′-nitroacetophenone (1.75 g, 7.2 mmol) was mixed with 50 mL of absolute EtOH along with thiourea (1.09 g, 14.4 mmol) and stirred under reflux for 2 hours. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The resulting residue was basified with 20 mL of 1 N aqueous NaOH and extracted with CH2Cl2. The combined organic layers were dried (Na2SO4) and concentrated to afford essentially quantitative yield of 4-(2-nitro-phenyl)-thiazol-2-ylamine.

1. custom4-(2-Nitro-phenyl)-thiazol-2-ylamine was prepared
2. temperatureunder reflux for 2 hours
3. concentrationconcentrated under reduced pressure
4. extractionextracted with CH2Cl2
5. dry with materialThe combined organic layers were dried (Na2SO4)
6. concentrationconcentrated